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Genetic Modification Of Lymphocytes By Vectors

This post categorized under Vector and posted on December 2nd, 2019.
Retrovirus Vector: Genetic Modification Of Lymphocytes By Vectors

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01.01.2000 Endowing T lymphocytes with novel functional attributes by genetic modification is under development for a broad range of clinical cellular immunotherapy applications. To cirgraphicvent many of the limitations graphicociated with viral vector systems a plasmid-based electroporation system that reliably generates G418-resistant primary human T Cited by 138Publish Year 2000Author Michael C. Jensen Patrick Clarke Giselle Tan Christine Wright Wen Chung-Chang Teresa N. Clark Highlights The retroviral toolbox for lymphocyte modification is constantly expanding. Chalgraphicges graphicociated with retroviruscell interactions still need to be addressed. Envelope modifications support the transduction of resting lymphocytes by graphictiviral vectors. Modifications to the integration pattern and transgene design address the risk of insertional mutagenesis. Further modifications in cargo design


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